Neonatal isoerythrolysis (NI)

Neonatal Isoerythrolysis (NI) is a haemolytic disease of newborn foals that have suckled and ingested colostral antibodies. The disease occurs when there is a difference of blood group between the stallion and the dam leading to a difference in blood group between the dam and the foal. Disease is most commonly seen where mares have been sensitised by a previous pregnancy. There are two antibodies that are most immunogenic – Aa and Qa. Mares that are negative for either Aa and Qa or both Aa and Qa are most at risk for causing this disease within their newborn foal, if these foals are positive.  




EDTA sample and serum sample from the mare (2 ml minimum volume)

EDTA sample from the stallion (for prediction of mare-stallion incompatibility)

EDTA sample from the foal (for prediction of mare-foal incompatibility)

Colostrum from the mare may also be used before the foal suckles.


EDTA (mare, stallion, foal) and plain/gel tube (mare)

Collection Protocol:

Standard venepuncture